تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Evaluation of a 49 InDel Marker HID panel in two specific populations of South America and one population of Northern Africa
Evaluation of a 49 InDel Marker HID panel in two specific populations of South America and one population of Northern Africa
 
لغة الوثيقة : الانجليزية 
المستخلص : The majority of STR loci are not ideal for the analysis of forensic samples with degraded and/or low template DNA. One alternative to overcome these limitations is the use of bi-allelic markers, which have low mutation rates and shorter amplicons. Human identification (HID) InDel marker panels have been described in several countries, including Brazil. The commercial kit available is, however, mostly suitable for Europeans, with lower discrimination power for other population groups. Recently, a combination of 49 InDel markers used in four different ethnic groups in the USA has been shown to be more informative than another panel from Portugal, already tested in a Rio de Janeiro sample. However, these 49 InDels have yet to be applied to other admixed or isolated populations. We assessed the efficiency of this panel in two urban admixed populations (Rio de Janeiro, Brazil; Tripoli, Libya) and one isolated Native Brazilian community. All markers are in Hardy-Weinberg equilibrium (HWE) after the Bonferroni correction, and no Linkage disequilibrium was detected. Assuming loci independence and no substructure effect, cumulative RMP was 2.7×10(-18), 1.5×10(-20), and 4.5×10(-20) for Native Brazilian, Rio de Janeiro, and Tripoli populations, respectively. The overall Fst value was 0.05512. Rio de Janeiro and Tripoli showed similar admixture levels, however for Native Brazilians one parental cluster represented over 60 % of the total parental population. We conclude that this panel is suitable for HID on these urban populations, but is less efficient for the isolated group. 
ردمد : 1437-1596 
اسم الدورية : Int J Legal Med 
المجلد : 129 
العدد : 2 
سنة النشر : 1436 هـ
2015 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, April 26, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
R. S. Moura-NetoMoura-Neto, R. S.باحث رئيسي rodrigomouraneto@ufrj.br
R. SilvaSilva, R. باحث مشارك  
I. C. MelloMello, I. C.باحث مشارك  
T. NogueiraNogueira, T. باحث مشارك  
ِِA. A. Al-DeibAl-Deib, A. A.باحث مشارك  
B. LaRueLaRue, B. باحث مشارك  
J. KingKing, J. باحث مشارك  
B. BudowleBudowle, B. باحث مشارك  

الملفات

اسم الملفالنوعالوصف
 38687.pdf pdf 

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