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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
iMiRNA-PseDPC: microRNA precursor identification with a pseudo distance-pair composition approach
iMiRNA-PseDPC: microRNA precursor identification with a pseudo distance-pair composition approach
 
لغة الوثيقة : الانجليزية 
المستخلص : A microRNA (miRNA) is a small non-coding RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene expression. The human genome may encode over 1000 miRNAs. Albeit poorly characterized, miRNAs are widely deemed as important regulators of biological processes. Aberrant expression of miRNAs has been observed in many cancers and other disease states, indicating that they are deeply implicated with these diseases, particularly in carcinogenesis. Therefore, it is important for both basic research and miRNA-based therapy to discriminate the real pre-miRNAs from the false ones (such as hairpin sequences with similar stem-loops). Particularly, with the avalanche of RNA sequences generated in the post-genomic age, it is highly desired to develop computational sequence-based methods for effectively identifying the human pre-miRNAs. Here, we propose a predictor called "iMiRNA-PseDPC", in which the RNA sequences are formulated by a novel feature vector called "pseudo distance-pair composition" (PseDPC) with 10 types of structure statuses. Rigorous cross-validations on a much larger and more stringent newly constructed benchmark data-set showed that our approach has remarkably outperformed the existing ones in either prediction accuracy or efficiency, indicating the new predictor is quite promising or at least may become a complementary tool to the existing predictors in this area. For the convenience of most experimental scientists, a user-friendly web server for the new predictor has been established at http://bioinformatics.hitsz.edu.cn/iMiRNA-PseDPC/, by which users can easily get their desired results without the need to go through the mathematical details. It is anticipated that the new predictor may become a useful high throughput tool for genome analysis particularly in dealing with large-scale data. 
ردمد : 0739-1102 
اسم الدورية : Journal of Biomolecular Structure and Dynamics 
المجلد : 34 
العدد : 1 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, May 2, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Bin LiuLiu, Bin باحث رئيسي  
Longyun FangFang, Longyun باحث مشارك  
Fule LiuLiu, Fule باحث مشارك  
Xiaolong WangWang, Xiaolong باحث مشارك  
Kuo-Chen ChouChou, Kuo-Chen باحث مشارك  

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