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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
iEnhancer-2L: a two-layer predictor for identifying enhancers and their strength by pseudo k-tuple nucleotide composition
iEnhancer-2L: a two-layer predictor for identifying enhancers and their strength by pseudo k-tuple nucleotide composition
 
لغة الوثيقة : الانجليزية 
المستخلص : Motivation: Enhancers are of short regulatory DNA elements. They can be bound with proteins (activators) to activate transcription of a gene, and hence play a critical role in promoting gene transcription in eukaryotes. With the avalanche of DNA sequences generated in the post-genomic age, it is a challenging task to develop computational methods for timely identifying enhancers from extremely complicated DNA sequences. Although some e􀁽orts have been made in this regard, they were limited at only identifying whether a query DNA element being of an enhancer or not. According to the distinct levels of biological activities and regulatory e􀁽ects on target genes, however, enhancers should be further classi􀂀ed into strong and weak ones in strength. Results: In view of this, a two-layer predictor called ‘iEnhancer-2L’ was proposed by formulating DNA elements with the ‘pseudo k-tuple nucleotide composition’, into which the six DNA local parameters were incorporated. To the best of our knowledge, it is the 􀂀rst computational predictor ever established for identifying not only enhancers, but also their strength. Rigorous cross-validation tests have indicated that iEnhancer-2L holds very high potential to become a useful tool for genome analysis. 
ردمد : 1460-2059 
اسم الدورية : Bioinformatics 
المجلد : 32 
العدد : 3 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, July 10, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Bin LiuLiu, Bin باحثدكتوراه 
Longyun FangFang, Longyun باحثدكتوراه 
Ren LongLong, Ren باحثدكتوراه 
Xun LanLan, Xun باحثدكتوراه 
Kuo-Chen ChouChou, Kuo-Chen باحثدكتوراه 

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اسم الملفالنوعالوصف
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