Main Page
Welcome
About the Center
About The SPC
Mission and Vision
Organizational Structure
Spc Directors
Facts and Figures
Services
ِActivities
Exhibitions
Print Exhibition
Books Exhibition
Visits
Training
Workshops
Courses
Seminars
Conventions
Celebrations
Research
Favorite Links
Contact Us
PhotoAlbum
Contact Us
Researches
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Scientific Publishing Center
Document Details
Document Type
:
Article In Journal
Document Title
:
The Uncoupling of Oxidative Phosphorylationof Mouse-Liver Mitochondria in vivo by Usnic Acid
منع تزامن الفسفرة التأكسدية في ميتوكوندريا كبد الفأرة الحي بواسطة حمض الأوزينك
Subject
:
Biological Sciences
Document Language
:
English
Abstract
:
(+) Usnic acid isolated from the local lichen species Usnea articulata had a median lethal dose of 180 mg/kg to mice (s.c. injection).The symptoms of the toxicity exhibited by (+) usnic acid was similar to those of classical uncouplers of oxidative phosphorylation.Mice injected with 200 mg/kg of (+) usnic acid produced significant uncoupling of isolated hepatic mitochondria. The signs of uncoupling included: release of respiratory control, inhibition of respiration (80% in the presence of ADP and 60% in its absence), hindering of ATP biosynthesis,and stimulation of Mg+2-ATPase activity (two-fold increase).In this respect, (+) usnic acid, a lipophilic weak acid with two ionizable hydrogens, acts in a similar fashion to many protonophoric uncouplers which dissipate the proton motive force (delta mu H+) across the inner mitochondrial membrane, therefore disrupting the tight coupling mechanism between electron transport and ATP synthesis.
ISSN
:
1012-1319
Journal Name
:
Science Journal
Volume
:
17
Issue Number
:
1
Publishing Year
:
1425 AH
2005 AD
Number Of Pages
:
10
Article Type
:
Article
Added Date
:
Sunday, October 11, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أحمد نبيل أبو خطوة
AHMED N. ABO-KHATWA
Researcher
علي أحمد الرباعي
ALI A. AL-ROBAI
Researcher
دينا عبدالعزيز الجوهري
DINA A. AL-JAWHARI
Researcher
Files
File Name
Type
Description
22480.pdf
pdf
Back To Researches Page