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Document Details
Document Type
:
Article In Journal
Document Title
:
Loss of growth hormone responsiveness to normal physiological stimuli during pregnancy
Loss of growth hormone responsiveness to normal physiological stimuli during pregnancy
Subject
:
Obstetrics and Gynecology
Document Language
:
English
Abstract
:
The response of pituitary GH to acute hyperglycaemia induced by 75 g oral glucose load in 73 pregnant women at various stages of gestation was examined. According to the age of gestation, patients were grouped into three groups: less than 20 weeks, between 20-30 and more than 30 weeks. Plasma glucose, GH and C-peptide were measured at fasting and then at 30, 60, 120 and 180 min following the glucose load. There was a significant increase in plasma GH concentration with weeks of gestation. The results also showed a loss of the normal physiological suppressive effects of hyperglycaemia on GH secretion in tests performed after 20 weeks of gestation. Only in tests performed before 20 weeks, there was a significant negative correlation between plasma glucose and GH values. These findings are consistent with recent reports suggesting an almost complete suppression of pituitary GH secretion by a placental variant of GH. These changes in the dynamics of GH secretion suggest that, in pregnancy, GH plays a more significant role than was previously thought
ISSN
:
0378-7346
Journal Name
:
Gynecologic and Obstetric Investigation
Volume
:
32
Issue Number
:
3
Publishing Year
:
1411 AH
1991 AD
Article Type
:
Article
Added Date
:
Sunday, April 3, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
حسن نصرت
Nasrat, Hasan
Investigator
Doctorate
محمد العرضاوي
Ardawi, Mohammed
Researcher
Doctorate
Files
File Name
Type
Description
29512.pdf
pdf
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