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Document Details
Document Type
:
Article In Journal
Document Title
:
Impact of hypertension, smoking and liver affection on endothelial dysfunction and subsequent vascular damage in Saudi middle aged males patients
Impact of hypertension, smoking and liver affection on endothelial dysfunction and subsequent vascular damage in Saudi middle aged males patients
Subject
:
Biochemistry
Document Language
:
English
Abstract
:
Endothelial dysfunction is one of the mechanisms linked to an increased risk of cardiovascular disease. To assess the impact of hypertension, smoking and past history of schistosomiasis on endothelial dysfunction and vascular damage in Saudi middle aged males who don't exercise regularly, the levels of soluble adhesion molecules E-selectin, ICAM-1 and VCAM-1, biomarkers of the activation of inflammatory cascades during the development of vascular injury, were determined. Plasma levels of sVCAM-1, sICAM-1 and sE-selectin were found to be elevated as a result of hypertension and/or cigarette smoking compared to normal counterparts. These results demonstrated that hypertension and cigarette smoking had the strongest direct associations with these biomarkers which are a reflection of their effect on endothelial dysfunction and subsequent vascular damage, while a past history of schistosomiasis had very little association with these biomarkers. These results also suggest that sVCAM-1 may be useful in assessing the impact of liver affliction, (as a result of schistosomiasis) on endothelial dysfunction.
ISSN
:
1214-021X
Journal Name
:
Journal of Applied Biomedicine
Volume
:
5
Issue Number
:
4
Publishing Year
:
1428 AH
2007 AD
Article Type
:
Article
Added Date
:
Saturday, December 17, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
خالد عمر أبو النجا
Abulnaja, Khalid O
Researcher
Doctorate
kabualnaja@kau.edu.sa
Files
File Name
Type
Description
31691.pdf
pdf
Abstract
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