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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
BRCA1 AND BRCA 2 MUTATIONS IN BREAST CANCER PATIENTS IN JEDDAH SAUDI ARABIA
طفرات جين BRCA1 و BRCA2 في مريضات سرطان الثدي بجدة في المملكة العربية السعودية
Subject
:
Faculty of Sciences
Document Language
:
Arabic
Abstract
:
Breast cancer is one of the major severe malignancies that affect women and occurs in either sporadic or hereditary form. The later affects five to ten percent of all cases and have distinct characteristics as compared to sporadic breast cancer. The discoveries of BRCA1 and BRCA2 remain one of the most important ones in human cancer genetics. Determination of the most penetrant mutations in these tumor suppressor genes has had a great impact on the woman breast cancer risks and their families. This research presents the study done on the distribution of the alleles of BRCA1 and BRCA2 genes in a sporadic breast cancer population in Jeddah. The study included 128 participants (50% control, 50% patients) and used Tetra ARMS-PCR primers technique for the detection of the missense mutation, c.4132G>A, exon 11 for BRCA1 and c.1385A>G in exon 10 for BRCA2. The results of the study indicated that (100%) of the genotype was normal allele (GG) for BRCA1, (98.44%) of the genotype was normal allele (AA) for BRCA2 while the control had (1.56%) for hetero allele (GA). At the moment, however, there is no enough proof to conclude that BRCA1 and BRCA2 mutations occur at a substantially lower frequency in KSA compared to the rest of the world.
Supervisor
:
Prof. Sabah Linjawi
Thesis Type
:
Master Thesis
Publishing Year
:
1438 AH
2017 AD
Co-Supervisor
:
Prof. Zuhoor algaithy
Added Date
:
Thursday, June 15, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
نوره يحى حمدي
Hamdi, Norah Yahya
Researcher
Master
Files
File Name
Type
Description
40903.pdf
pdf
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