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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Phytochemical and Biological Studies of Echinops macrochetus
دراسات كيميائية نباتية وبيولوجية على إكينوبس ماكروشيتوس
Subject
:
faculty of Pharmacy
Document Language
:
Arabic
Abstract
:
Two new rare sesquiterpene glycosides, macrochaetosides A (3) and B (4), together with two known metabolites: stigmasterol (1) and cyclostenol (2) were separated from the CHCl3 fraction of the aerial parts of Echinops macrochaetus Fresen (Asteraceae). Their chemical structures were established on the basis various spectroscopic methods in addition to mass spectrometry and comparison with literature data. Moreover, the cytotoxic activity of these metabolites was assessed towards MCF-7, HepG2, and HCT-116 tumour cell lines using sulphorhodamine B assay (SRB). Compounds 2 and 3 showed a potent cytotoxic profile towards all tested cell lines with IC50s 2.1, 2.9, and 3.6 µM and 1.9, 3.3, and 2.3 µM, respectively. However, 4 exhibited cytotoxic activity against MCF-7 with IC50 6.9 µM.
Supervisor
:
Prof. Dr. Hossam Mohamed Abdallah
Thesis Type
:
Master Thesis
Publishing Year
:
1441 AH
2020 AD
Added Date
:
Tuesday, June 9, 2020
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
تغريد عبدالجليل زمزمي
Zamzami, Taghreed Abduljalee
Researcher
Master
Files
File Name
Type
Description
46339.pdf
pdf
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